Second Malignancy
Gaps in Knowledge
Why do most patients not get a second neoplasm?
- Host factors
- Behaviors
- Genetics
- Tumor characteristics
- What we can and cannot modify
- Investigating links between the epidemiology and the underlying biology (e.g., XRT associated SNs)
Opportunities
- Concepts that could be developed
- Secondary breast CA biology
- Other analysis of SN's
- Host biology and risk of SN's
- Planned comparisons of current and expanded CCSS cohort
- Interventional studies
- Breast
- Behavioral
- Biological
- NMSS
- Behavioral
- Biological
- Breast
Request for Submission of Topic-specific RFA
- Biologically based
- Specific aims should include:
- Genetic predisposition (measure what you think is correct)
- Correlation with therapy received
- End result will increase our understanding of pathobiology of secondary neoplasia
Topics Under Discussion
- Salivary gland tumors (international collaboration; Lead: Inskip)
- SN's and Wilm's Tumor (international collaboration; Lead: Breslow)
- Radiation sensitivity genes (Lead: Davis / Mertens)