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About the CCSS
Organizational Structure
Study Aims
Collaborating Institutions And Principal Investigators
Site Map
Develop a Study
Process Overview
Applications Of Intent
Analysis Concept Proposals
Approved Concept Proposals
Ancillary Studies
Working Groups
GWAS Data Resource
Whole Genome Data
Biospecimens
Buccal Cell Collection
Saliva Collection
Biospecimen Tables
Subsequent Malignant Neoplasms
Public Access Data
Overall CCSS Cohort Demographic and Treatment Exposure Tables
Public Access Data Tables
Published Research
Publications
Abstracts
Tools & Documents
CCSS Questionnaires
Survey Question Set Matrix
Progress Reports
Investigator Meetings
Calculators & Other Tools
Participant Newsletters
Summary Statistics for Published Analyses
Home
Develop a Study
Working Groups
Genetics
Current Page
Genetics
Gaps in Knowledge, Future Opportunities
Evaluate genetic contribution to initial childhood cancer, multiple primary tumors and other late effects
Biospecimen repository up front for new cohort to include probands and parents, new samples on existing cohort
New focused web-based family history questionnaire for existing and expanded cohorts
Offspring cohort, biospecimens not dependent on proband survival
Genetic predisposition to complement the outstanding repository of data on childhood cancer, treatment and late effects
Tumor-specific genetic changes, dependent on tumor / normal resources
Tissue or histology specific?
Treatment specific?
Genetic predisposition-specific?
Genetic testing / counseling in Long-Term Survivor Study participants and families
Ethics and genetic testing in CCSS
"Biomarkers" of increased SMN genetic risk
Significance of change in cancer family history over time