Gaps in Knowledge
- Renal outcomes
- GI outcomes
- Bone density in adult survivors
- Fracture risk
- Interaction between normal aging process and major organ dysfunction, especially cardiovascular
- Interaction between cardiovascular risk factors (e.g., insulin resistance, dyslipidemia), direct organ damage from prior therapy (e.g., anthracycline, RT), and lifestyle choices (e.g., smoking, alcohol)
Opportunities for Proposals Using Existing Data
- GI outcomes
- Renal outcomes
- Solid organ transplants
- Infectious complications
Opportunities for Proposals Using Future Data
- Interactions of cardiovascular risk factors, lifestyle choices, treatment exposures and cardiovascular mortality
- Impact of aging on burden of chronic medical conditions
- Incidence and risk factors for bone fracture
- Renal / tubular dysfunction in expanded cohort
Opportunities for Ancillary Studies
- Direct measurement studies
- Assessment of markers for cardiovascular disease (e.g., fasting insulin / glucose, CRP, lipids) in subset of survivors
- Assessment of bone mineral density in subset of survivors
- Blood indices of chronic organ system dysfunction (e.g., BUN, creat)
- Intervention studies to reduce risk (e.g., exercise, diet) in survivors at high risk for cardiovascular disease
Request for Submission of Topic-specific RFA
- Studies designed to improve our understanding of the interaction between metabolic risk factors for CVD, cardiotoxic therapeutic exposures, and lifestyle choices on CVD disease and CV mortality
- Studies designed to assess incidence of and risk factors for reduced BMD in adult survivors of childhood cancer
Topics Under Discussion
- GI complications
- GU complications
- Genetic risk factors for ovarian failure