Subsequent Malignant Neoplasms

The Biopathology Center of the CCSS, located at Nationwide Children's Hospital in Columbus, Ohio, is the central repository for tumor tissue samples and confirmation of diagnoses of subsequent malignancies from treating institutions of CCSS cohort participants who report a subsequent cancer.

Characteristics of Subsequent Neoplasms in CCSS, October 2020
Subsequent Neoplasm Total Cases Ascertained Initial Cohort Expansion Cohort Ascertained during Current Grant Period
  N % N % % N %
All Subsequent Neoplasms 9317 100.0 7252 100.0 2065 100.0 5647 100.0
Leukemia 86 0.9 60 0.8 26 1.3 22 0.4
ALL 19 0.2 16 0.2 3 0.1 4 0.1
AML 50 0.5 32 0.4 18 0.9 13 0.2
Other Leukemia 17 0.2 12 0.2 5 0.2 5 0.1
Lymphoma 87 0.9 64 0.9 23 1.1 38 0.7
Hodgkin Lymphoma 21 0.2 15 0.2 6 0.3 5 0.1
Non-Hodgkin Lymphoma 65 0.7 48 0.7 17 0.8 33 0.6
Other Lymphoma 1 0.0 1 0.0 0 .0.0 0 0.0
CNS 919 9.9 723 10.0 196 9.5 541 9.6
Glial 145 1.6 85 1.2 60 2.9 54 1.0
Medulloblastoma/PNET 8 0.1 7 0.1 1 0.0 1 0.0
Meningioma 730 7.8 603 8.3 127 6.2 477 8.4
Other CNS 36 0.4 28 0.4 8 0.4 9 0.2
Solid Organ 1818 19.5 1369 18.9 449 21.7 816 14.5
Breast 668 7.2 547 7.5 121 5.9 284 5.0
Bone 66 0.7 50 0.7 16 0.8 12 0.2
Soft tissue sarcoma 220 2.4 159 2.2 61 3.0 78 1.4
Thyroid 389 4.2 247 3.4 142 6.9 184 3.3
Other solid organ 475 5.1 366 5.0 109 5.3 258 4.6
Skin 6003 64.4 4733 65.3 1270 61.5 3951 70.0
Melanoma 163 1.7 119 1.6 44 2.1 95 1.7
Non-melanoma skin cancer 5840 62.7 4614 63.6 1226 59.4 3856 68.3
Unspecified cancer 404 4.3 303 4.2 101 4.9 279 4.9

Paraffin tumor material is collected and sent to the Center for storage for future studies. Material for over 730 tumors is stored in the Pediatric Division of the National Cancer Institute's Cooperative Human Tissue Network (CHTN) in Columbus.