Depending on what level of treatment information is available, we created three different prediction models:

  • Simple (if anthracycline, alkylator, platinum-agent chemotherapy, and radiation exposures to the brain, neck, and chest are known, but not the doses)
  • Standard (if anthracycline and field-specific radiation doses are known)
  • Standard+heart (if anthracycline dose and heart-specific radiation dosimetry are known)
  • A subsequent analysis based on CCSS data alone (Chen et al.) extended the Standard model to survivors of childhood cancer currently ages 20 to 39 (Standard+Age), and incorporates information on diabetes, dyslipidemia, and hypertension status.

To determine one's risk of cardiovascular disease using these models, please enter the information below (All fields are Required):

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Calculation Results

Using the for survivors who are 5-years from cancer diagnosis::

  • The overall risk score is
  • The estimated probability of developing Heart Failure by 50 years of age is (95% confidence interval = )
  • The relative risk of developing Heart Failure compared to a non-cancer sibling comparison is (95% confidence interval = )
  • Data Used For Calculation

    Could not be estimated. Simple model requires information on sex, diagnosis age, anthracycline and chest radiation exposures.

    Using the for survivors who are 5-years from cancer diagnosis:

    • The overall risk score is
    • The estimated probability of developing Ischemic Heart Disease by 50 years of age is (10-year probability = )
    • The relative risk of developing Ischemic Heart Disease compared to a non-cancer sibling comparison group is (95% confidence interval = )
    • Data Used For Calculation

      Could not be estimated. Simple model requires information on sex, diagnosis age, neck and chest radiation exposures

      Using the for survivors who are 5-years from cancer diagnosis:

      • The overall risk score is
      • The estimated probability of developing Stroke by 50 years of age is (10-year probability = )
      • The relative risk of developing Stroke compared to a non-cancer sibling comparison group is (95% confidence interval = )
      • Data Used For Calculation

        Could not be estimated. Simple model requires information on alkylator, platinum agent, and brain radiation exposure.

        For additional details on Risk, see the table.