Depending on what level of treatment information is available, we created three different prediction models:

- Simple (if anthracycline, alkylator, platinum-agent chemotherapy, and radiation exposures to the brain, neck, and chest are known, but not the doses)
- Standard (if anthracycline and field-specific radiation doses are known)
- Standard+heart (if anthracycline dose and heart-specific radiation dosimetry are known)
- A subsequent analysis based on CCSS data alone (Chen et al.) extended the Standard model to survivors of childhood cancer currently ages 20 to 39 (Standard+Age), and incorporates information on diabetes, dyslipidemia, and hypertension status.

To determine one's risk of cardiovascular disease using these models, please enter the information below **(All fields are Required)**:

## Calculation Results

Using the for survivors who are 5-years from cancer diagnosis::

- The overall risk score is
- The estimated probability of developing Heart Failure by 50 years of age is (95% confidence interval = )
- The relative risk of developing Heart Failure compared to a non-cancer sibling comparison is (95% confidence interval = )
- Data Used For Calculation

Could not be estimated. Simple model requires information on sex, diagnosis age, anthracycline and chest radiation exposures.

Using the for survivors who are 5-years from cancer diagnosis:

- The overall risk score is
- The estimated probability of developing Ischemic Heart Disease by 50 years of age is (10-year probability = )
- The relative risk of developing Ischemic Heart Disease compared to a non-cancer sibling comparison group is (95% confidence interval = )
- Data Used For Calculation

Could not be estimated. Simple model requires information on sex, diagnosis age, neck and chest radiation exposures

Using the for survivors who are 5-years from cancer diagnosis:

- The overall risk score is
- The estimated probability of developing Stroke by 50 years of age is (10-year probability = )
- The relative risk of developing Stroke compared to a non-cancer sibling comparison group is (95% confidence interval = )
- Data Used For Calculation

Could not be estimated. Simple model requires information on alkylator, platinum agent, and brain radiation exposure.