Your Resource > Ancillary Study List
The table below lists all CCSS Ancillary Studies. You can search the list by using one or both methods below:
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| Title | PI/Institution | Funding Source | Status | Study Aims | Citation |
|---|---|---|---|---|---|
| Premature Menopause in Survivors of Childhood Cancer | Charles Sklar (Memorial Sloan Kettering Cancer Center) | National Institutes of Health (R01 CA79024) | Funded | Examine the prevalence and risk factors for premature menopause and associated psychosexual functioning in a cohort of 5500 young adult female survivors of cancer diagnosed during childhood and adolescence. |
J Clin Endocrinol Metab. 2006 May;91(5):1723-8. J Natl Cancer Inst 2006 Jul 5;98(13):890-6 |
| Smoking Cessation among Childhood Cancer Survivors | Karen Emmons (Harvard University) | National Institutes of Health (R01 CA77780) | Funded | Conduct a randomized intervention trial to test a peer-based smoking cessation program for long-term survivors of childhood cancer. |
J Clin Oncol. 2003 Jan 15;21(2):189-96. J Clin Oncol 2005 Sep 20;23(27):6516-23 Prev Med. 2006 Jun;42(6):435-42. J Clin Oncol. 2009 Jan 1;27(1):52-60. |
| Mammography and High-Risk Survivors of Pediatric Cancer | Kevin Oeffinger (Memorial Sloan Kettering Cancer Center) | National institute of Health (R21 CA106972) | Funded | Evaluate the prevalence of and factors predictive for mammography among long-term survivors of childhood cancer who are at high-risk for radiation-induced breast cancer. | JAMA 2009 Jan 28;301(4):404-14 |
| Metabolic Syndrome in Adult Survivors of Childhood acute Lymphoblastic Leukemia | James Gurney (University of Minnesota) | National Institutes of Health (R21 CA1068778) | Funded | Evaluate clinically the metabolic syndrome and associations with growth hormone deficiency and endothelial impairment as late effects of treatment for childhood acute lymphoblastic leukemia. | Cancer 2006 Sep 15;107(6):1303-12 Pediatr Blood Cancer. 2007; 49(7): 975-81. Ann Epidemiol 2007; 17: 778-81. J Pediatr Hemotol Oncol 2008; 30: 20-25 J Pediatr Hematol Oncol 2008; 30: 815-22 Cancer 2008; 113: 3248-56. |
| Health Outcomes for Hodgkin Disease Survivors | Debra Friedman (University of Washington) | National Institutes of Health (R01 CA106897) | Funded | Examine the cumulative incidence and characterize the spectrum of selected adverse physiologic and psychosocial outcomes in contemporarily treated Hodgkin disease survivors. | |
| Late Effects in Survivors of Childhood Acute Myeloid Leukemia | H Stacy Nicholson (Oregon Health Sciences Center) | National Institutes of Health (R01 CA78960) | Funded | Evaluate the occurrence of late effects among five-year survivors of childhood acute myeloid leukemia to compare the risks associated with intensive therapy, including bone marrow transplantation. | |
| Safety/Efficacy of Growth Hormone Therapy in Survivors of Childhood Cancer | Charles Sklar (Memorial Sloan Kettering Cancer Center) | Genentech Foundation | Funded | Evaluate the use of growth hormone therapy in survivors of childhood cancer to determine potential impact on final height, risk of cancer-recurrence, and risk of second neoplasm. |
J Clin Endocrinol Metab. 2002 Jul;87(7):3136-41. J Clin Endocrinol Metab. 2004 Sep;89(9):4422-7. J Clin Endocrinol Metab. 2006 Sep;91(9):3494-8. |
| Radiation Dosimetry for Childhood Cancer Survivors | Ann Mertens (University of Minnesota) | Lance Armstrong Foundation | Funded | Estimate tissue-specific dose of radiation received by survivors of childhood cancer who experience selected adverse outcomes within the context of a nested case-control study. | Lancet 2005; 365: 2014-23. Radiat Res. 2006; 166: 618-628 J Clin Oncol. 2009: 27: 3901-7. |
| Health Profiles in Adolescent Survivors of Childhood Cancer | Ann Mertens (University of Minnesota) | American Cancer Society | Funded | Investigate the physical, cognitive and emotional development of adolescent survivors of childhood cancer to aid in development interventions to improve quality of life. | |
| Psychosocial, Behavioral and Pain Outcomes in Survivors of Childhood Cancer | Lonnie Zeltzer (UCLA) | Lance Armstrong Foundation | Funded | Determine, within the CCSS cohort, the prevalence and risk factors for psychosocial outcomes in long-term survivors of childhood and adolescent cancer. | J Clin Oncol. 2004; 22: 999-1006. Pediatr Blood and Cancer 2007; 49: 47-51. |
| Preconception Radiation and Reproductive Outcomes among Survivors of Childhood Cancer | John Boice (International Epidemiology Institute) | Westlakes Research Institute | Funded | Investigate the potential risk of transgenerational effects among the offspring of survivors of childhood cancer in the USA and Denmark who were treated with radiation. | J Natl Cancer Inst. 2006 Oct 18;98(20):1453-61. |
| Feasibility Study for Project VISION: A Virtual Information Center for Survivors | Kevin Oeffinger (Memorial Sloan Kettering Cancer Center) | Lance Armstrong Foundation | Funded | Assess the feasibility of a randomized clinical trial using a virtual information center as a cognitive-based intervention with survivors and health care providers. | |
| Patient Perceived Barriers to Long-Term Follow-up for Adult Survivors of Childhood Cancer | Kevin Oeffinger (Memorial Sloan Kettering Cancer Center) | Robert Wood Johnson Foundation | Funded | Determine the spectrum of, and characteristics predictive for barriers to cancer-related health care of adult survivors of childhood cancer. | Ann Family Med 2004;2:61-70 Cancer 2009;115:642-54. |
| Function and Quality of Life of Survivors of Pediatric Lower Limb Tumors | Rajaram Nagarajan (University of Minnesota) | ASCO (Young Investigator Award) and NCCF (Fellowship Award) | Funded | Investigate the function, quality of life, and psychosocial outcomes of adult survivors of pediatric lower extremity bone tumors to compare amputation and limb-sparing surgeries within age-specific groups. | J Cancer Surviv 2009;3(1):59-65 |
| Testicular and sexual dysfunction in adult survivors of childhood cancer | Lillian Meacham (Emory University) | Lance Armstrong Foundation | Funded | Investigate the psychosexual function of male long-term survivors of childhood cancer to determine the prevalence of and risk factors for physiological and psychological adverse outcomes. | |
| Adult Neurobehavioral Late Effects of Pediatric Low Grade Brain Tumors | Douglas Ris (University of Cincinnati) | National Institutes of Health (R01 - CA132899-01A1) | Funded | Ascertain the presence, degree and nature of neuropsychological dysfunction in adults treated as children for low grade brain tumors and to investigate accelerated cognitive aging. | |
| Health Beliefs and Behavior: Cohort Studies in Pediatric Cancer Survivorship | Tara Henderson (University of Chicago) | National Institutes of Health (K07 Award funded July 2008) | Funded | Characterize barriers and facilitators of breast cancer surveillance, diagnosis and therapy in women with secondary breast cancer, and explore associations between breast cancer surveillance practices, initial method of detection, health beliefs and breast cancer outcomes. | |
| Efficacy of a Tobacco Quit Line for Childhood Cancer Survivors | Robert Klesges (St. Jude Children's Research Hospital) | National Institutes of Health (R01 CA127964-02) | Funded | To conduct a randomized intervention trial designed to test the efficacy of Pro-active versus Reactive approach for smoking cessation. | |
| Environmental Exposure: Susceptibility alleles in a DNA damage response pathway | Peter Stambrook (University of Cincinnati) | National Institutes of Health (1R01 ES016625-01A1) | Funded | Define genetic changes a signaling pathway that contribute to susceptibility to breast cancer after environmental exposure. | |
| Prediction Model for Radiation Sensitivity in Children with Cancer | Stella Davies (Cincinnati Children's Hospital Medical Center) | National Cancer Institute | Funded | To identify genetic polymorphisms related to BCC following radiation. | |
| The Genetics of Secondary Cancer | Kenan Onel (University of Chicago) | National Cancer Institute (R21) | Funded | Detailed genomic and functional analysis of inborn susceptibilities in another SMN, IR-induced SMN in Hodgkin disease survivors. | |
| Are Adult Survivors of Childhood Cancer Underinsured? | Elyse Park (Dana Farber Cancer Institute) | Lance Armstrong Foundation | Funded | To compare survivor's and sibling's quality of coverage, perceptions of coverage, consequences of inadequate coverage and coverage-related concerns. To examine survivors' and siblings' knowledge regarding relevant legislations. | |
| Investigating the needs of childhood cancer survivors: The unreported experience (INSURE) | Cheryl Cox (St. Jude Children's Research Hospital) | National Cancer Institute (R21) | Funded | Evaluate the psychometric and item-response performance of a needs assessment survey; evaluate sample selection participants and response rates to inform future longitudinal needs assessment surveys. | |
| Symptom Cluster Subgroups in Adult Survivors of Childhood Cancers | Lorna Finnegan (University of Illinois at Chicago) | National Institutes of Health, National Cancer Institute (R01CA136912) | Funded | Identify subgroups using a five-symptom cluster including pain, fatigue, sleep disturbance, psychological stress, difficulty concentrating to determine relations with influencing factors (e.g., cancer type, treatment modality, etc.). | |
| Projecting Absolute Breast Cancer Risk Following Radiotherapy in Survivors of Childhood Cancer | Chaya Moskowitz (Memorial Sloan Kettering Cancer Center) | National Institutes of Health (R01) | Funded | Determine association of dose of chest radiation, additional treatment factors, and traditional breast cancer risk factors associated with risk of breast cancer among childhood cancer survivors, then develop a breast cancer risk prediction tool. | |
| Encourage Mammography and Prevention Opportunities for Women Exposed to Radiation | Kevin Oeffinger (Memorial Sloan Kettering Cancer Center) | National Institutes of Health (R01 CA77780) | Funded | Determine efficacy of stepwise two-component intervention on mammography rates and explore moderating and mediating factors. | |
| A Longitudinal Study of Pain in Long-term Survivors of Childhood Cancer | Qian Lu (UCLA) | Lance Armstrong Foundation | Submitted | To determine the potential impact of chronic pain on overall quality of life among cancer survivors. | |
| Radiation Dose and Risk of Non-Melanoma Skin Cancer in Cancer Survivors | Ann Mertens (University of Minnesota) | Lance Armstrong Foundation | Funded | Investigate radiation does and the subsequent risk of non-melanoma skin cancer in cancer survivors. | Cancer. 2009;115(18 Suppl):4374-84. |
| Evaluation of Cardiovascular Outcomes Among Childhood Cancer Survivors (ECHOS) | Melissa Hudson, Cheryl Cox (St. Jude Children's Research Hospital) | National Institutes of Health (R01) | Funded | Assess the efficacy of the intervention in increasing the rate of CV screening and to identify changes in survivor behavioral characteristics in response to the intervention, their mediating effects on the primary outcome, and the cost-effectiveness of the intervention. | |
| The Impact of Childhood Cancer Survivorship on Parental Psychosocial Outcomes, Health, and Aging | Whitney Witt (University of Wisconsin) | National Institutes of Health (R01) | Proposed | Identify the factors related to poor psychosocial outcomes (stress and family burden) among parents of long-term survivors of childhood cancer. | |
| Genetic Susceptibility to Obesity after Treatment for Childhood Leukemia | Kayla Kamdar (Baylor) | Leukemia & Lymphoma Society Translational Research Program | Proposed | Using genome-wide and candidate pathway analyses, this study aims to identify genetic variants and ultimately key biological pathways that are involved in the development of obesity |