Gaps in Knowledge

  • Interventions for targeted subgroups of survivors at risk for pain
  • Pathways to resilience

Opportunities for Proposals Using Existing Data

  • Status of survivors whose questionnaires have been completed by proxy
  • Symptom clusters

Opportunities for Proposals Using Future Data

  • Pain and symptom clusters in the new cohort: predictors and pathways
  • New treatments for brain tumors: cognitive and functional outcomes

Opportunities for Ancillary Studies

Non-intervention research
  • Assessment of cognitive function, emotional regulation, and physical function in low grade astrocytomas
  • Association between polymorphisms related to increased pain in cancer populations (e.g., COMT) and to increased stress and pain, psychological, and HRQOL outcomes
Intervention research
  • Interventions targeted at subgroups with pain

Request for Submission of Topic-specific RFA

  • Targeted evaluations and interventions for subgroups of survivors with cognitive deficits and neurologic / chronic health condition co-morbidities; including identification of the subgroup who still have proxy informers (novel proxy interventions)