Gaps in Knowledge, Future Opportunities

• Evaluate genetic contribution to initial childhood cancer, multiple primary tumors and other late effects
  • Biospecimen repository up front for new cohort to incude probands and parents, new samples on existing cohort
  • New focused web-based family history questionnaire for existing and expanded cohorts
  • Offspring cohort, biospecimens not dependent on proband survival
  • Genetic predisposition to complement the outstanding repository of data on childhood cancer, treatment and late effects
• Tumor-specific genetic changes, dependent on tumor / normal resources
  • Tissue or histology specific?
  • Treatment specific?
  • Genetic predisposition-specific?
• Genetic testing / counseling in Long-Term Survivor Study participants and families
• Ethics and genetic testing in CCSS
• "Biomarkers" of increased SMN genetic risk
• Significance of change in cancer family history over time

• Working Groups
• Approved Concept Proposals
• Working Group: Biostatistics/Epidemiology
• Working Group: Cancer Control
• Working Group: Chronic Disease
• Working Group: Neurology
• Working Group: Psychology
• Working Group: Reproductive Outcomes
• Working Group: Second Malignancy